{"id":20210,"date":"2025-11-05T11:29:15","date_gmt":"2025-11-05T11:29:15","guid":{"rendered":"https:\/\/www.pidsphil.org\/home\/?page_id=20210"},"modified":"2025-11-05T14:07:33","modified_gmt":"2025-11-05T14:07:33","slug":"journal-2025-vol-26-no-2-original-articles-3","status":"publish","type":"page","link":"https:\/\/www.pidsphil.org\/home\/journal-2025-vol-26-no-2-original-articles-3\/","title":{"rendered":"Journal 2025 Vol.26 No.2 Original Articles 3"},"content":{"rendered":"

Journal 2025 Vol.26 No.2<\/span><\/strong><\/b>
\nFactors Associated with Poor Clinical Outcomes in Patients with Multisystem Inflammatory Syndrome in Children in a Tertiary Level Hospital: A retrospective, cross-sectional, descriptive study <\/b>
\nMarie Louise S. Lukban, M.D., Robert Dennis J. Garcia, M.D.<\/strong><\/em><\/p>\n

Abstract <\/b>
\nIntroduction: <\/b>Multisystem Inflammatory Syndrome in Children (MIS-C) is a delayed hyperinflammatory condition affecting multiple organ systems. Prominent symptoms include fever, skin rashes, and gastrointestinal symptoms, manifesting prior to critical signs such as cardiac involvement, hypotension, and shock.
\nObjective:<\/b> To determine if certain demographic, clinical, and laboratory markers are predictive of poor outcomes in patients diagnosed with MIS-C.
\nMethod: <\/b>This is a retrospective, cross-sectional study (2020-2023) of children who met the 2020 CDC MIS-C criteria. Data on demographics, comorbidities, clinical course, outcomes, laboratory results and 2D Echocardiogram findings were obtained and analyzed.
\nResults: <\/b>There were 28 patients with MIS-C, with a median age of 4.5 years. The majority of patients were male (64%). The percentage of neutrophils showed a significant association with hypotension\/shock (OR 1.16). White blood cell count (WBC) and ferritin were significantly associated with ICU admission (OR 3.5 and 2.9, respectively). Pericardial effusion was observed in 71.4% while myocarditis was present in 67.9% of patients. The most notable risk factor was HIV infection, which was significantly associated with a more than 50-fold increase in the odds of developing ARDS and 165-fold increase in the odds of mortality; there was only one mortality, and only one patient with documented HIV infection.
\nConclusions: <\/b>The outcome was good in non-immunocompromised patients and the only recorded mortality was a patient not previously known to have HIV. We identified statistically significant factors that were associated with adverse outcome measures, with the limitation of a small sample, such as HIV infection and risk for ARDS and mortality; elevated neutrophil percentage and risk for hypotension\/shock; elevated WBC and ferritin and risk for ICU admission; and saw a high prevalence of pericardial effusion and myocarditis in these patients, highlighting the critical role of hyperinflammation and cardiac involvement in disease progression and outcome.<\/p>\n

KEYWORDS: <\/b>MIS-C, COVID-19, Inflammatory, Risk Factors<\/i>
\nhttps:\/\/doi.org\/10.56964\/pidspj20252602004<\/strong><\/a>
\n|\u00a0View Full Article in PDF format<\/a>\u00a0|<\/strong><\/p>\n<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-20210","page","type-page","status-publish","hentry"],"yoast_head":"\nJournal 2025 Vol.26 No.2 Original Articles 3 - Pediatric Infectious Disease Society of the Philippines<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pidsphil.org\/home\/journal-2025-vol-26-no-2-original-articles-3\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Journal 2025 Vol.26 No.2 Original Articles 3 - Pediatric Infectious Disease Society of the Philippines\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pidsphil.org\/home\/journal-2025-vol-26-no-2-original-articles-3\/\" \/>\n<meta property=\"og:site_name\" content=\"Pediatric Infectious Disease Society of the Philippines\" \/>\n<meta property=\"article:modified_time\" content=\"2025-11-05T14:07:33+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.pidsphil.org\\\/home\\\/journal-2025-vol-26-no-2-original-articles-3\\\/\",\"url\":\"https:\\\/\\\/www.pidsphil.org\\\/home\\\/journal-2025-vol-26-no-2-original-articles-3\\\/\",\"name\":\"Journal 2025 Vol.26 No.2 Original Articles 3 - Pediatric Infectious Disease Society of the Philippines\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.pidsphil.org\\\/home\\\/#website\"},\"datePublished\":\"2025-11-05T11:29:15+00:00\",\"dateModified\":\"2025-11-05T14:07:33+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.pidsphil.org\\\/home\\\/journal-2025-vol-26-no-2-original-articles-3\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.pidsphil.org\\\/home\\\/journal-2025-vol-26-no-2-original-articles-3\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.pidsphil.org\\\/home\\\/journal-2025-vol-26-no-2-original-articles-3\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.pidsphil.org\\\/home\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Journal 2025 Vol.26 No.2 Original Articles 3\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.pidsphil.org\\\/home\\\/#website\",\"url\":\"https:\\\/\\\/www.pidsphil.org\\\/home\\\/\",\"name\":\"Pediatric Infectious Disease Society of the Philippines\",\"description\":\"Pediatric Infectious Disease Society of the Philippines\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.pidsphil.org\\\/home\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Journal 2025 Vol.26 No.2 Original Articles 3 - Pediatric Infectious Disease Society of the Philippines","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pidsphil.org\/home\/journal-2025-vol-26-no-2-original-articles-3\/","og_locale":"en_US","og_type":"article","og_title":"Journal 2025 Vol.26 No.2 Original Articles 3 - Pediatric Infectious Disease Society of the Philippines","og_url":"https:\/\/www.pidsphil.org\/home\/journal-2025-vol-26-no-2-original-articles-3\/","og_site_name":"Pediatric Infectious Disease Society of the Philippines","article_modified_time":"2025-11-05T14:07:33+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.pidsphil.org\/home\/journal-2025-vol-26-no-2-original-articles-3\/","url":"https:\/\/www.pidsphil.org\/home\/journal-2025-vol-26-no-2-original-articles-3\/","name":"Journal 2025 Vol.26 No.2 Original Articles 3 - Pediatric Infectious Disease Society of the Philippines","isPartOf":{"@id":"https:\/\/www.pidsphil.org\/home\/#website"},"datePublished":"2025-11-05T11:29:15+00:00","dateModified":"2025-11-05T14:07:33+00:00","breadcrumb":{"@id":"https:\/\/www.pidsphil.org\/home\/journal-2025-vol-26-no-2-original-articles-3\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.pidsphil.org\/home\/journal-2025-vol-26-no-2-original-articles-3\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.pidsphil.org\/home\/journal-2025-vol-26-no-2-original-articles-3\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.pidsphil.org\/home\/"},{"@type":"ListItem","position":2,"name":"Journal 2025 Vol.26 No.2 Original Articles 3"}]},{"@type":"WebSite","@id":"https:\/\/www.pidsphil.org\/home\/#website","url":"https:\/\/www.pidsphil.org\/home\/","name":"Pediatric Infectious Disease Society of the Philippines","description":"Pediatric Infectious Disease Society of the Philippines","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.pidsphil.org\/home\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/pages\/20210","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/comments?post=20210"}],"version-history":[{"count":7,"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/pages\/20210\/revisions"}],"predecessor-version":[{"id":20251,"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/pages\/20210\/revisions\/20251"}],"wp:attachment":[{"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/media?parent=20210"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}