{"id":20210,"date":"2025-11-05T11:29:15","date_gmt":"2025-11-05T11:29:15","guid":{"rendered":"https:\/\/www.pidsphil.org\/home\/?page_id=20210"},"modified":"2025-11-05T14:07:33","modified_gmt":"2025-11-05T14:07:33","slug":"journal-2025-vol-26-no-2-original-articles-3","status":"publish","type":"page","link":"https:\/\/www.pidsphil.org\/home\/journal-2025-vol-26-no-2-original-articles-3\/","title":{"rendered":"Journal 2025 Vol.26 No.2 Original Articles 3"},"content":{"rendered":"

Journal 2025 Vol.26 No.2<\/span><\/strong><\/b>
\nFactors Associated with Poor Clinical Outcomes in Patients with Multisystem Inflammatory Syndrome in Children in a Tertiary Level Hospital: A retrospective, cross-sectional, descriptive study <\/b>
\nMarie Louise S. Lukban, M.D., Robert Dennis J. Garcia, M.D.<\/strong><\/em><\/p>\n

Abstract <\/b>
\nIntroduction: <\/b>Multisystem Inflammatory Syndrome in Children (MIS-C) is a delayed hyperinflammatory condition affecting multiple organ systems. Prominent symptoms include fever, skin rashes, and gastrointestinal symptoms, manifesting prior to critical signs such as cardiac involvement, hypotension, and shock.
\nObjective:<\/b> To determine if certain demographic, clinical, and laboratory markers are predictive of poor outcomes in patients diagnosed with MIS-C.
\nMethod: <\/b>This is a retrospective, cross-sectional study (2020-2023) of children who met the 2020 CDC MIS-C criteria. Data on demographics, comorbidities, clinical course, outcomes, laboratory results and 2D Echocardiogram findings were obtained and analyzed.
\nResults: <\/b>There were 28 patients with MIS-C, with a median age of 4.5 years. The majority of patients were male (64%). The percentage of neutrophils showed a significant association with hypotension\/shock (OR 1.16). White blood cell count (WBC) and ferritin were significantly associated with ICU admission (OR 3.5 and 2.9, respectively). Pericardial effusion was observed in 71.4% while myocarditis was present in 67.9% of patients. The most notable risk factor was HIV infection, which was significantly associated with a more than 50-fold increase in the odds of developing ARDS and 165-fold increase in the odds of mortality; there was only one mortality, and only one patient with documented HIV infection.
\nConclusions: <\/b>The outcome was good in non-immunocompromised patients and the only recorded mortality was a patient not previously known to have HIV. We identified statistically significant factors that were associated with adverse outcome measures, with the limitation of a small sample, such as HIV infection and risk for ARDS and mortality; elevated neutrophil percentage and risk for hypotension\/shock; elevated WBC and ferritin and risk for ICU admission; and saw a high prevalence of pericardial effusion and myocarditis in these patients, highlighting the critical role of hyperinflammation and cardiac involvement in disease progression and outcome.<\/p>\n

KEYWORDS: <\/b>MIS-C, COVID-19, Inflammatory, Risk Factors<\/i>
\nhttps:\/\/doi.org\/10.56964\/pidspj20252602004<\/strong><\/a>
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