{"id":19879,"date":"2025-06-13T10:06:58","date_gmt":"2025-06-13T10:06:58","guid":{"rendered":"https:\/\/www.pidsphil.org\/home\/?page_id=19879"},"modified":"2025-11-19T23:55:43","modified_gmt":"2025-11-19T23:55:43","slug":"journal-2025-vol-26-no-1-original-articles-3","status":"publish","type":"page","link":"https:\/\/www.pidsphil.org\/home\/journal-2025-vol-26-no-1-original-articles-3\/","title":{"rendered":"Journal 2025 Vol.26 No.1 Original Articles 3"},"content":{"rendered":"

Journal 2025 Vol.26 No.1<\/span><\/strong><\/b>
\nOutcomes of the use of Ceftazidime-avibactam among patients admitted in the neonatal intensive care unit with multidrug-resistant Klebsiella hospital-acquired sepsis <\/b>
\nVince Elic S. Maullon, M.D., Sally Jane Velasco-Aro, M.D.<\/strong><\/em><\/p>\n

Abstract <\/b>
\nBackground <\/b>The use of ceftazidime-avibactam (CAZ-AVI) has been recently introduced to combat multidrug\u0002resistant organisms (MDROs) in the pediatric population. Case reports have documented the successful off-label use of CAZ-AVI in the treatment of MDRO sepsis in neonates; however, data remains to be limited, especially in the Philippines.
\nObjectives:<\/b> This study aims to explore the effects of CAZ-AVI on clinical outcomes including mortality rate, length of hospital stay since treatment initiation, and bacteriological eradication among patients admitted at the NICU with MDR Klebsiella hospital-acquired sepsis. Other objectives include comparing these outcomes betwee those who received CAZ-AVI (in combination with aztreonam, ATM) and those who received other 2nd line MDR\u0002antibiotic regimens used for carbapenem-resistant Klebsiella growths, as well as exploring the association of factors such as gestational age and age at sepsis diagnosis of patients with their outcomes post-treatment with CAZ-AVI\u00b1 ATM.
\nMethodology: <\/b>This is a retrospective cohort study of admitted patients in a neonatal intensive care unit of a tertiary hospital with MDR Klebsiella hospital-acquired sepsis across a two-year period. A review of medical records was done, and data were collected and analyzed.
\nResults: <\/b>There were a total 11 patients treated with CAZ-AVI \u00b1 ATM compared with 11 patients given other 2nd line antibiotic treatment regimens. The use of CAZ-AVI \u00b1 ATM exhibited a trend towards a decreased mortality rate (54.5%, p = 0.17), shorter length of hospital stays from treatment initiation (30.7 days, p = 0.50), and increased bacteriological eradication rates (63.6%, p < 0.05), compared with other 2nd line antibiotic treatment regimens, regardless of gestational age and age at sepsis diagnosis.
\nConclusion: <\/b>The use of CAZ-AVI \u00b1 ATM showed a more favorable trend compared with other 2nd line antimicrobials for with MDR Klebsiella hospital-acquired sepsis. These observations, however, require further confirmation with a prospective study, a longer study period, and an increase in sample size.<\/p>\n

KEYWORDS: <\/b>Ceftazidime-avibactam, multidrug-resistant Klebsiella hospital-acquired sepsis, neonates<\/i>
\nhttps:\/\/doi.org\/10.56964\/pidspj20252601004<\/strong><\/a>
\nView Full Article in PDF format<\/a>\u00a0<\/strong><\/p>\n<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-19879","page","type-page","status-publish","hentry"],"yoast_head":"\nJournal 2025 Vol.26 No.1 Original Articles 3 - Pediatric Infectious Disease Society of the Philippines<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pidsphil.org\/home\/journal-2025-vol-26-no-1-original-articles-3\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Journal 2025 Vol.26 No.1 Original Articles 3 - Pediatric Infectious Disease Society of the Philippines\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pidsphil.org\/home\/journal-2025-vol-26-no-1-original-articles-3\/\" \/>\n<meta property=\"og:site_name\" content=\"Pediatric Infectious Disease Society of the Philippines\" \/>\n<meta property=\"article:modified_time\" content=\"2025-11-19T23:55:43+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.pidsphil.org\\\/home\\\/journal-2025-vol-26-no-1-original-articles-3\\\/\",\"url\":\"https:\\\/\\\/www.pidsphil.org\\\/home\\\/journal-2025-vol-26-no-1-original-articles-3\\\/\",\"name\":\"Journal 2025 Vol.26 No.1 Original Articles 3 - 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