{"id":19691,"date":"2024-11-28T00:03:57","date_gmt":"2024-11-28T00:03:57","guid":{"rendered":"https:\/\/www.pidsphil.org\/home\/?page_id=19691"},"modified":"2025-06-14T01:03:03","modified_gmt":"2025-06-14T01:03:03","slug":"journal-2024-vol-25-no-2-original-articles-2","status":"publish","type":"page","link":"https:\/\/www.pidsphil.org\/home\/journal-2024-vol-25-no-2-original-articles-2\/","title":{"rendered":"Journal 2024 Vol.25 No.2 Original Articles 2"},"content":{"rendered":"

Journal 2024 Vol.25 No.2<\/span><\/strong>
\nSeropositivity of Anti-HBs Titer Among College Students Several Years After <\/b>Completion of the Primary Hepatitis B Vaccination Series <\/b>
\nMonique P. Valerio-Fabros, M.D., Jay Ron O. Padua, M.D.<\/em>
\nAbstract<\/b>
\nBackground:<\/b>\u00a0<\/i><\/b>The Philippines is hyperendemic for hepatitis B infection. Vaccination is crucial for protection. Local data on the antibody response after completion of the primary vaccination series is limited.
\nObjective: <\/b>This study aimed to measure the anti-HBs levels among college students who completed primary hepatitis B vaccination series, compare seropositivity across stratified groups and correlate anti-HBs levels with the time elapsed since the last vaccine dose.
\nMethods: <\/b>This cross-sectional study included 111 college students in health-related courses with immunization record showing the complete primary Hepatitis B vaccination series. Participants were stratified based on the following vaccination schedules: 0-1-6-month group; 0-1-2-month group; and booster group. Anti-HBs titers were determined.
\nData Analysis: <\/b>Statistical analyses included One-way ANOVA, Kruskal-Wallis test, Fisher\u2019s Exact test and Shapiro-Wilk normality test. Kaplan-Meier Survival Estimate assessed the probability of anti-HBs seropositivity over time. Data were analyzed using STATA 13.1.
\nResults: <\/b>The baseline characteristics of the study population were homogenous. The median anti-HBs titer several years after primary vaccination was low at 2.9 mIU\/mL. Participants in the booster group had the highest seropositivity rate (57.14%) with a median titer of 30.16 mIU\/mL. There was an inverse relationship between anti-HBs titer and elapsed time since the last vaccine dose. Kaplan-Meier Survival Estimate showed that the seropositivity decreases to 90.56% after 15.8 years, 51.3% after 17.5 years, and 2.97% at 18 years.
\nConclusion: <\/b>This study revealed low anti-HBs titers among students who previously completed primary vaccination series, with no significant difference between two schedules. Booster doses resulted in the highest seropositivity. Over-all, seropositivity declines over time.
\nKeywords: <\/b>Hepatitis B, Hepatitis B Antibodies<\/i>, <\/i><\/b>Primary Hepatitis B Vaccination<\/i>
\nhttps:\/\/doi.org\/10.56964\/pidspj20242502003<\/strong><\/a>
\nView Full Article in PDF format<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Journal 2024 Vol.25 No.2 Seropositivity of Anti-HBs Titer Among College Students Several Years After Completion of the Primary Hepatitis B Vaccination Series Monique P. Valerio-Fabros, M.D., Jay Ron O. Padua, M.D. Abstract Background:\u00a0The Philippines is hyperendemic for hepatitis B infection. Vaccination is crucial for protection. Local data on the antibody response after completion of the […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-19691","page","type-page","status-publish","hentry"],"yoast_head":"\nJournal 2024 Vol.25 No.2 Original Articles 2 - Pediatric Infectious Disease Society of the Philippines<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pidsphil.org\/home\/journal-2024-vol-25-no-2-original-articles-2\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Journal 2024 Vol.25 No.2 Original Articles 2 - Pediatric Infectious Disease Society of the Philippines\" \/>\n<meta property=\"og:description\" content=\"Journal 2024 Vol.25 No.2 Seropositivity of Anti-HBs Titer Among College Students Several Years After Completion of the Primary Hepatitis B Vaccination Series Monique P. Valerio-Fabros, M.D., Jay Ron O. Padua, M.D. Abstract Background:\u00a0The Philippines is hyperendemic for hepatitis B infection. Vaccination is crucial for protection. 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Valerio-Fabros, M.D., Jay Ron O. Padua, M.D. Abstract Background:\u00a0The Philippines is hyperendemic for hepatitis B infection. Vaccination is crucial for protection. 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