{"id":19015,"date":"2023-11-23T08:59:12","date_gmt":"2023-11-23T08:59:12","guid":{"rendered":"https:\/\/www.pidsphil.org\/home\/?page_id=19015"},"modified":"2025-06-14T02:39:28","modified_gmt":"2025-06-14T02:39:28","slug":"journal-2023-vol-24-no-2-original-articles-7","status":"publish","type":"page","link":"https:\/\/www.pidsphil.org\/home\/journal-2023-vol-24-no-2-original-articles-7\/","title":{"rendered":"Journal 2023 Vol.24 No.2 Original Articles 7"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1206.4px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-text fusion-text-1\"><p><strong><b><span style=\"color: #800000;\">Journal 2023 Vol.24 No.2<\/span><\/b><br \/>\nClinical Profile and Treatment Outcomes Of Acute Cholangitis in Children in a Tertiary Government Hospital in the Philippines: A Five-Year Retrospective Study<\/strong><br \/>\n<em><strong>Arianne L. Calimlim-Samson, M.D., FPPS, DPIDSP, Carmina A. delos Reyes, M.D., FPPS, FPIDSP, Germana Emerita V. Gregorio, M.D., MSc, PhD<\/strong><\/em><br \/>\n<strong>Abstract<\/strong><br \/>\n<strong>Background:<\/strong> Acute cholangitis (AC) in children is a rare but life-threatening infection. Symptoms vary from mild to severe disease. There are no local published data on pediatric AC.<br \/>\n<strong>Objective:<\/strong> To determine the clinical, biochemical, ultrasonographic, microbiologic features, and treatment outcome of pediatric patients with definite AC.<br \/>\n<strong>Methodology:<\/strong> Cross-sectional study using medical records of pediatric patients diagnosed with definite AC based on the Modified Tokyo Guidelines of 2018 admitted from January 2016 to June 2021.<br \/>\n<strong>Results:<\/strong> Twenty-seven patients aged 0 to 18 years old (10.06 + 7.34), predominantly male (51.85%) were included. Choledocholithiasis (22%) and post-Kasai biliary atresia (22%) were the common underlying biliary conditions. Fever (88.89%) was the most frequent presenting symptom. Majority were classified as moderate AC (40.74%). Leukocytosis (mean 16&#215;109\/L), elevated inflammatory markers (93.33% with CRP &gt;12mg\/L and 100% with serum procalcitonin &gt;0.25ng\/mL), hyperbilirubinemia (total bilirubin 192.54\u00b1126.87umol\/L) and elevated alanine transferases (mean 59 IU\/L) were noted. Twenty-one out of 27 cases (87%) had a negative blood culture. Only 4<br \/>\npatients underwent bile culture, of which two (50%) grew Klebsiella pneumoniae resistant to empiric antibiotics. Dilated biliary ducts were observed on abdominal ultrasound in 92.59% of patients. Ampicillin-sulbactam (29.63%) was the most commonly utilized antibiotic. Discharge rate was high (88.89%).<br \/>\n<strong>Conclusions:<\/strong> AC affects all pediatric age groups but clinical presentations vary. Drug resistant organisms are a significant concern but despite this, favorable outcomes have been documented.<\/p>\n<p><strong>Keywords:<\/strong> Cholangitis, Children, Choledocholithiasis<br \/>\n<a href=\"https:\/\/doi.org\/10.56964\/pidspj20232402008\">https:\/\/doi.org\/10.56964\/pidspj20232402008<\/a><br \/><strong><a class=\"fullscreen-mode\" href=\"https:\/\/www.pidsphil.org\/home\/themencode-pdf-viewer\/?file=https:\/\/www.pidsphil.org\/home\/wp-content\/uploads\/2023\/11\/9-PIDSPJ-242-Original-Article-Calimlim-Samson-et-al.pdf#zoom=auto\">Fullscreen Mode<\/a><br \/><iframe class=\"pvfw-pdf-viewer-frame\" width=\"100%\" height=\"800\" src=\"https:\/\/www.pidsphil.org\/home\/themencode-pdf-viewer\/?file=https:\/\/www.pidsphil.org\/home\/wp-content\/uploads\/2023\/11\/9-PIDSPJ-242-Original-Article-Calimlim-Samson-et-al.pdf#zoom=auto&amp;pagemode=none\"><\/iframe> <\/strong><\/p>\n<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-19015","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/pages\/19015","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/comments?post=19015"}],"version-history":[{"count":4,"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/pages\/19015\/revisions"}],"predecessor-version":[{"id":19935,"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/pages\/19015\/revisions\/19935"}],"wp:attachment":[{"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/media?parent=19015"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}