{"id":19012,"date":"2023-11-23T08:54:20","date_gmt":"2023-11-23T08:54:20","guid":{"rendered":"https:\/\/www.pidsphil.org\/home\/?page_id=19012"},"modified":"2025-06-14T02:43:17","modified_gmt":"2025-06-14T02:43:17","slug":"journal-2023-vol-24-no-2-original-articles-6","status":"publish","type":"page","link":"https:\/\/www.pidsphil.org\/home\/journal-2023-vol-24-no-2-original-articles-6\/","title":{"rendered":"Journal 2023 Vol.24 No.2 Original Articles 6"},"content":{"rendered":"<p><strong><b><span style=\"color: #800000;\">Journal 2023 Vol.24 No.2<\/span><\/b><\/strong><br \/>\n<strong>SARS-CoV-2 RT-PCR Cycle Threshold Value and Its Association with Disease Severity and Mortality among Hospitalized Pediatric COVID-19 Patients <\/strong><br \/>\n<em><strong>Aubrey O. Artienda, M.D. and Jay Ron O. Padua, M.D.<\/strong><\/em><br \/>\n<strong>Abstract<\/strong><br \/>\n<strong>Objective:<\/strong> This study determined the association of SARS-CoV-2 RT-PCR cycle threshold (Ct) value with disease severity and mortality among hospitalized pediatric COVID-19 patients.<br \/>\n<strong>Methodology:<\/strong> This is a retrospective cohort study of patients aged 0-18 years with SARS-CoV-2 RT-PCR-confirmed COVID-19 from 1-September-2020 to 31-August-2022. The cohort was divided into those with high (&gt;30), medium (&gt; 20) and low (&lt;\/= 20) Ct values. Association between Ct values and disease severity was determined using Chi-square test and association between Ct values and mortality was determined using logistic regression.<br \/>\n<strong>Results:<\/strong> There were 236 patients included with male predominance. Median age was 7 years. Most belonged to the 0-5 years age group. Most were severe to critical COVID-19 cases. Median day of illness on swab collection was 4 days. Majority presented with symptoms such as fever (54%), cough (22%) and dyspnea (22%). Eighty-four percent had co-morbidities, of which majority were cancer and neurologic diseases. Median Ct value was 30.81. Fifty-four percent had high Ct values. The median age of patients with a high Ct value was significantly lower than other cohorts. The median day of illness of patients with low Ct value was significantly shorter than other cohorts. There<br \/>\nwas no significant difference across the terciles in terms of presence of co-morbidities. Majority of patients for each cohort had high Ct values. There was no significant association between Ct value and COVID-19 disease severity on admission. Nearly fifty percent had critical disease and the all-cause mortality rate was 21.61%. There was no significant association between Ct value and mortality.<br \/>\n<strong>Conclusions:<\/strong> Ct value was not associated with disease severity and all-cause mortality after controlling for confounders. A look into medical interventions, emergence of variants, and other factors that may affect the clinical presentation, disease course, severity and outcome are recommended in future studies.<\/p>\n<p><strong>Keywords:<\/strong> COVID-19, Cycle Threshold Value, Disease Severity, Mortality, Outcome, Pediatric Patients<br \/>\n<a href=\"https:\/\/doi.org\/10.56964\/pidspj20232402007\">https:\/\/doi.org\/10.56964\/pidspj20232402007<\/a><br \/>\n<strong><a href=\"https:\/\/www.pidsphil.org\/home\/wp-content\/uploads\/2023\/11\/8-PIDSJ-242-Original-Article-Artienda-et-al.pdf\" target=\"_\" rel=\"noopener\">View Full Article in PDF format<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Journal 2023 Vol.24 No.2 SARS-CoV-2 RT-PCR Cycle Threshold Value and Its Association with Disease Severity and Mortality among Hospitalized Pediatric COVID-19 Patients Aubrey O. Artienda, M.D. and Jay Ron O. Padua, M.D. Abstract Objective: This study determined the association of SARS-CoV-2 RT-PCR cycle threshold (Ct) value with disease severity and mortality among hospitalized pediatric COVID-19  [&#8230;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-19012","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/pages\/19012","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/comments?post=19012"}],"version-history":[{"count":3,"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/pages\/19012\/revisions"}],"predecessor-version":[{"id":19936,"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/pages\/19012\/revisions\/19936"}],"wp:attachment":[{"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/media?parent=19012"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}