{"id":19009,"date":"2023-11-23T08:49:32","date_gmt":"2023-11-23T08:49:32","guid":{"rendered":"https:\/\/www.pidsphil.org\/home\/?page_id=19009"},"modified":"2025-06-14T02:39:02","modified_gmt":"2025-06-14T02:39:02","slug":"journal-2023-vol-24-no-2-original-articles-5","status":"publish","type":"page","link":"https:\/\/www.pidsphil.org\/home\/journal-2023-vol-24-no-2-original-articles-5\/","title":{"rendered":"Journal 2023 Vol.24 No.2 Original Articles 5"},"content":{"rendered":"

Journal 2023 Vol.24 No.2<\/span><\/b><\/strong>
\nMulti-system Inflammatory Syndrome in Children (MIS-C) in Two Private, Urban, Tertiary Hospitals in Metro Manila, Philippines<\/strong>
\nRobert Dennis J. Garcia, M.D., MHSA<\/strong><\/em>
\nAbstract<\/strong>
\nBackground:<\/strong> MIS-C is an infrequent, but serious complication encountered after acquiring COVID-19 illness in children. There is a lack of local data on MIS-C in the Philippines.
\nObjective: To identify demographic data, co-morbidities, clinical manifestations, laboratory results, 2D-echocardiography findings, acute co-illnesses and complications, treatment, and outcome of children with MIS-C, seen in two, private, urban, tertiary hospitals.
\nMethodology:<\/strong> This is a retrospective, descriptive study of all consecutive MIS-C cases, using the 2020 US CDC definition, seen between July 2020 to January 2023, by a single infectious disease physician. Demographic, epidemiologic, clinical, and physical examination findings; results of laboratory, 2-DE, and radiologic tests; co-illnesses and complications; and therapeutic and outcome data, were entered in a case report form for each patient.
\nResults:<\/strong> Thirty-six patients were seen. MIS-C cases had a median age of 6 years, presented with fever in 97%, while one-half had abdominal pain, vomiting, diarrhea and\/or rash. CRP, D-dimer, ferritin, LDH and procalcitonin were generally elevated, and thrombocytopenia was seen in 39%. The most common 2-DE abnormalities were pericardial effusion (50%), coronary artery dilatation or aneurysm (39%) and mitral regurgitation (36%); the 2-DE was normal in 22%. The main complications were pneumonia (31%), myocarditis (28%) and hypotension (14%); 8% had ARDS. Treatment was with corticosteroids (89%) and IVIG (84%). Most (94%) recovered, and the hospital stay
\nwas five days, or less, in 86%. The two mortalities were a severely wasted adolescent with previously undiagnosed HIV infection; and an adolescent on chemotherapy for AML, who was also being treated for disseminated TB.
\nConclusions:<\/strong> There is a need to create a greater awareness of MIS-C as, like Kawasaki disease, it has the potential to be an important cause of acquired heart disease among children.<\/p>\n

Keywords:<\/strong> MIS-C, Filipino, Pediatric
\nhttps:\/\/doi.org\/10.56964\/pidspj20232402006<\/a>
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