{"id":18990,"date":"2023-11-23T08:12:54","date_gmt":"2023-11-23T08:12:54","guid":{"rendered":"https:\/\/www.pidsphil.org\/home\/?page_id=18990"},"modified":"2025-06-14T02:37:33","modified_gmt":"2025-06-14T02:37:33","slug":"journal-2023-vol-24-no-2-original-articles-1","status":"publish","type":"page","link":"https:\/\/www.pidsphil.org\/home\/journal-2023-vol-24-no-2-original-articles-1\/","title":{"rendered":"Journal 2023 Vol.24 No.2 Original Articles 1"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1206.4px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-text fusion-text-1\"><p><strong><b><span style=\"color: #800000;\">Journal 2023 Vol.24 No.2<\/span><\/b><\/strong><br \/>\n<strong>The Coronavirus Disease 2019 (COVID-19) Immunoglobulin (IgG) Levels Using Chemiluminescence Immunoassay (CLIA) Anti-S-RBD Test in Term Neonates Born to COVID-19 Fully Vaccinated Mothers<\/strong><br \/>\n<strong><em>Ray C. Mendoza II, M.D., Belle M. Ranile, M.D., Nathalie Anne Hernaez, M.D.<\/em><\/strong><br \/>\n<b>Abstract<\/b><br \/>\n<b>Background: <\/b>Though protective levels of neonatal SARS-CoV2 IgG still warrant further studies, maternal antibodies from COVID-19 vaccination may be the key to neonatal protection against COVID-19 related complications. This study aimed to correlate SARS-CoV2 IgG titers of term newborns delivered to fully vaccinated\/boosted mothers with the time of dose completion to delivery and the type of COVID-19 vaccine received by the mothers.<br \/>\n<b>Methodology: <\/b>A single center prospective cohort study that utilized CLIA Anti-S-RBD IgG determination in cord blood was done. Kruskal-Wallis and Mann-Whitney U Test were used to determine significant differences between IgG titers from vaccine types and groups as to trimester when COVID-19 dose was completed. Spearman\u2019s rank was used to determine the correlation between IgG levels and interval of dose completion to delivery.<br \/>\n<b>Results: <\/b>All 177 newborns enrolled in the study had reactive results (&gt; 1 AU\/ml) regardless of vaccine type received and trimester of maternal vaccination completion. The highest titers recorded per group was 19,340 AU\/ml from the booster group and 5,960 AU\/ml from the primary series group. The mRNA vaccinated group exhibited higher titers compared to other vaccine types regardless of the trimester completion for both groups.<br \/>\n<b>Conclusions: <\/b>A significant difference between IgG levels showed that higher titers were noted in the booster group compared to the primary series group across all trimesters. There was also a significant correlation between titer levels and time of dose completion to delivery with higher titers associated with more recent dose completion for both groups.<\/p>\n<p><b>Keywords: <\/b>SARS-CoV2 IgG S-RBD, COVID-19 Vaccine, Neonates<br \/>\n<a href=\"https:\/\/doi.org\/10.56964\/pidspj20232402002\">https:\/\/doi.org\/10.56964\/pidspj20232402002<\/a><br \/><strong><a class=\"fullscreen-mode\" href=\"https:\/\/www.pidsphil.org\/home\/themencode-pdf-viewer\/?file=https:\/\/www.pidsphil.org\/home\/wp-content\/uploads\/2023\/11\/3-PIDSPJ-242-Original-Article-Mendoza-et-al.pdf#zoom=auto\">Fullscreen Mode<\/a><br \/><iframe class=\"pvfw-pdf-viewer-frame\" width=\"100%\" height=\"800\" src=\"https:\/\/www.pidsphil.org\/home\/themencode-pdf-viewer\/?file=https:\/\/www.pidsphil.org\/home\/wp-content\/uploads\/2023\/11\/3-PIDSPJ-242-Original-Article-Mendoza-et-al.pdf#zoom=auto&amp;pagemode=none\"><\/iframe> <\/strong><\/p>\n<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-18990","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/pages\/18990","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/comments?post=18990"}],"version-history":[{"count":7,"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/pages\/18990\/revisions"}],"predecessor-version":[{"id":19930,"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/pages\/18990\/revisions\/19930"}],"wp:attachment":[{"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/media?parent=18990"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}