{"id":17504,"date":"2022-08-29T04:53:34","date_gmt":"2022-08-29T04:53:34","guid":{"rendered":"http:\/\/www.pidsphil.org\/home\/?page_id=17504"},"modified":"2025-06-14T04:56:16","modified_gmt":"2025-06-14T04:56:16","slug":"journal-2018-vol-19-no-2-original-articles-5","status":"publish","type":"page","link":"https:\/\/www.pidsphil.org\/home\/journal-2018-vol-19-no-2-original-articles-5\/","title":{"rendered":"Journal 2018 Vol.19 No.2 Original Articles 5"},"content":{"rendered":"<p><strong><span class=\"journalTitle\"><span style=\"color: #800000;\">Journal 2018 Vol.19 No.2<\/span><\/span><\/strong><br \/>\n<strong>Outcome of Current Antibiotic Regimens used for Neonatal Sepsis in a Tertiary Hospital<\/strong><br \/>\n<em><strong>Anne Melva V. Meliton-Ruiz, M.D., Robert Dennis J. Garcia, M.D.<\/strong><\/em><br \/>\n<strong>Abstracts<br \/>\nObjective: <\/strong>This paper looked into the outcome of currently used antibiotic regimens for neonatal sepsis in a tertiary hospital.<strong><br \/>\nMethods: <\/strong>This retrospective study reviewed all cases of culture positive neonatal sepsis delivered in a tertiary hospital between January 1, 2000 to December 31, 2015. Demographic profile, stratification as to early-onset and late-onset sepsis, clinical manifestations, culture and antimicrobial susceptibility results, and outcomes were analyzed.<strong><br \/>\nResults: <\/strong>There were 28 cases of culture positive neonatal sepsis reported during the study period, and prematurity and low birth weight were the major risk factors identified. Of these, 8 were early-onset sepsis and 20 were late-onset sepsis cases. Respiratory symptoms were the most common presenting manifestations. Sepsis isolates were evenly distributed between gram-negative bacilli and gram-positive cocci with no ESBL E. coli or Klebsiella pneumoniae identified. The institution\u2019s current empiric antibiotic regimen of cefuroxime and amikacin for early-onset neonatal sepsis was shifted to another drug in 57% of cases. Piperacillintazobactam or carbapenem was given for late-onset sepsis. The addition of vancomycin for late-onset sepsis was done where Staphylococcus was considered. Sepsis due to gram-negative bacilli had a high mortality rate.<strong><br \/>\nConclusion: <\/strong>Our institution\u2019s empiric antibiotic regimen which consists of cefuroxime and amikacin for early onset sepsis is effective in 43% of cases. A carbapenem or piperacillin-tazobactam, even without amikacin, proved to be effective for late-onset sepsis. Vancomycin, should be considered for late-onset sepsis, if staphyloccoccal disease is suspected.<strong><br \/>\nKeywords: <\/strong>neonatal sepsis, antibiotic, neonate, low birth weight<br \/>\n<strong><a href=\"https:\/\/doi.org\/10.56964\/pidspj20181902007\">https:\/\/doi.org\/10.56964\/pidspj20181902007<\/a><br \/>\n<a href=\"https:\/\/www.pidsphil.org\/home\/wp-content\/uploads\/2019\/05\/Vol-19-No-2_RUIZ_Antibiotic-Regimens-Revised7.pdf\" target=\"_\" rel=\"noopener\">View Full Article in PDF format<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Journal 2018 Vol.19 No.2 Outcome of Current Antibiotic Regimens used for Neonatal Sepsis in a Tertiary Hospital Anne Melva V. Meliton-Ruiz, M.D., Robert Dennis J. Garcia, M.D. Abstracts Objective: This paper looked into the outcome of currently used antibiotic regimens for neonatal sepsis in a tertiary hospital. Methods: This retrospective study reviewed all cases of  [&#8230;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-17504","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/pages\/17504","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/comments?post=17504"}],"version-history":[{"count":5,"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/pages\/17504\/revisions"}],"predecessor-version":[{"id":20060,"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/pages\/17504\/revisions\/20060"}],"wp:attachment":[{"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/media?parent=17504"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}