{"id":17485,"date":"2022-08-29T04:39:06","date_gmt":"2022-08-29T04:39:06","guid":{"rendered":"http:\/\/www.pidsphil.org\/home\/?page_id=17485"},"modified":"2025-06-14T04:53:28","modified_gmt":"2025-06-14T04:53:28","slug":"journal-2018-vol-19-no-1-original-articles-6","status":"publish","type":"page","link":"https:\/\/www.pidsphil.org\/home\/journal-2018-vol-19-no-1-original-articles-6\/","title":{"rendered":"Journal 2018 Vol.19 No.1 Original Articles 6"},"content":{"rendered":"<p><strong><span class=\"journalTitle\"><span style=\"color: #800000;\">Journal 2018 Vol.19 No.1<\/span><\/span><\/strong><br \/>\n<strong>A Retrospective Study on the Outcome of Children with Extensively Drug-Resistant Gram-Negative Infection Treated with Colistin vs. Other Antimicrobials<\/strong><br \/>\n<em><strong>Carren Anne P. Batalla &#8211; Bocaling, M.D., Estrella B. Paje &#8211; Villar, M.D.<\/strong><\/em><br \/>\n<strong>Abstract<\/strong><br \/>\n<strong>Introduction: <\/strong>The increasing trend of extensively drug-resistant gram-negative infections led to the reconsideration of colistin as a valuable therapeutic option.<br \/>\n<strong>Objectives: <\/strong>To describe the clinical profile and treatment response of children with extensively drug resistant (XDR) Gram-negative infections given colistin versus other antimicrobials.<br \/>\n<strong>Methods: <\/strong>This retrospective descriptive study involved patients treated for XDR Gram-negative infections from January 2014 to June 2017 in a tertiary hospital in Metro Manila. Descriptive statistics were used to summarize clinical characteristics of subjects.<br \/>\nTreatment response to colistin versus other antimicrobial agents were compared in terms of success, failure, and toxicity. The Fisher-exact and Mann Whitney U tests were used to assess statistical differences between the colistin and non-colistin groups.<br \/>\n<strong>Results: <\/strong>Majority of patients with XDR Gramnegative infections had previous antibiotic exposure.<br \/>\nMore patients in the colistin group received TPN 43.2% vs 23.7% (p=0.035), had a longer hospital stay prior to the onset of XDR Gram-negative infection, 27 days vs. 15.5 days (p=0.001), and had a longer total hospital stay with a median of 52 days vs 30 days (p &lt; 0.001). Treatment success was significantly higher in the colistin group at 70.3%, as against 46.5% in the non-colistin group (p=0.014). There was no difference in the treatment duration of both groups. The colistin group had longer time to clinical response, with a mean of 6.27 (+ 3.57) days compared with those from the non-colistin group, with a mean of 4.36 (+ 1.77)(p=0.008). The colistin group had more fungal infections during the course of treatment (p=0.001).<br \/>\n<strong>Conclusion: <\/strong>Based on our institutional experience, colistin is considered relatively effective and safe in treating XDR Gram-negative infections in children.<br \/>\n<strong>Keywords: <\/strong>extensively drug-resistant gram-negative infection, healthcare associated infection, colistin<br \/>\n<strong><a href=\"https:\/\/doi.org\/10.56964\/pidspj20181901008\">https:\/\/doi.org\/10.56964\/pidspj20181901008<\/a><\/strong><br \/>\n<strong><a href=\"https:\/\/www.pidsphil.org\/home\/wp-content\/uploads\/2019\/02\/jo54_ja07.pdf\" target=\"_\" rel=\"noopener\">View Full Article in PDF format<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Journal 2018 Vol.19 No.1 A Retrospective Study on the Outcome of Children with Extensively Drug-Resistant Gram-Negative Infection Treated with Colistin vs. Other Antimicrobials Carren Anne P. Batalla &#8211; Bocaling, M.D., Estrella B. Paje &#8211; Villar, M.D. Abstract Introduction: The increasing trend of extensively drug-resistant gram-negative infections led to the reconsideration of colistin as a valuable  [&#8230;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-17485","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/pages\/17485","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/comments?post=17485"}],"version-history":[{"count":6,"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/pages\/17485\/revisions"}],"predecessor-version":[{"id":20053,"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/pages\/17485\/revisions\/20053"}],"wp:attachment":[{"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/media?parent=17485"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}