{"id":17471,"date":"2022-08-29T04:30:57","date_gmt":"2022-08-29T04:30:57","guid":{"rendered":"http:\/\/www.pidsphil.org\/home\/?page_id=17471"},"modified":"2025-06-14T04:52:47","modified_gmt":"2025-06-14T04:52:47","slug":"journal-2018-vol-19-no-1-original-articles-1","status":"publish","type":"page","link":"https:\/\/www.pidsphil.org\/home\/journal-2018-vol-19-no-1-original-articles-1\/","title":{"rendered":"Journal 2018 Vol.19 No.1 Original Articles 1"},"content":{"rendered":"<p><strong><span class=\"journalTitle\"><span style=\"color: #800000;\">Journal 2018 Vol.19 No.1<\/span><\/span><\/strong><br \/>\n<strong>A Prospective Cross-Sectional Study on the Prevalence and Factors Associated with Seroprotection after Primary Series of Hepatitis B Vaccination<\/strong><br \/>\n<em><strong>Adrienne Michelle B. Lu, M.D., Maria Estela R. Nolasco, M.D., Marilou G. Tan, M.D.<\/strong><\/em><br \/>\n<strong>Abstract<\/strong><br \/>\n<strong>Objectives: <\/strong>To determine the prevalence and factors associated with seroprotection among children 3 months to 18 years old with primary Hepatitis B vaccination series.<br \/>\n<strong>Methodology: <\/strong>This is a prospective cross-sectional study done among children 3 months to 18 years old with complete primary series of Hepatitis B vaccination. Demographic, social and clinical data were correlated with reactivity to antibody to Hepatitis B surface antigen (antiHBs) (&gt;10 IU\/L),total antibody to Hepatitis B core antigen (total anti-HBc) and Hepatitis B surface antigen (HBsAg) serologic tests.<br \/>\n<strong>Results: <\/strong>Among 110 subjects from different age groups,52% had seroprotective anti-HBs levels, with the highest noted among infants (3 months-2 years) at 82%, followed by 41% from the childhood group (3-9 years) and 26% from adolescent group (10-18 years). Seventy-four percent of subjects with &lt;5 years interval from vaccination were seroprotected, 26% in subjects after 5-10 years, and 38% at more than 10 years after vaccination with significant difference on multi-logistic regression (p value 0.000\/0.020). None of the other factors including gender, geographic area, age at first dose, vaccination schedule, type and place of vaccination were significantly associated with seroprotection.<br \/>\n<strong>Conclusion: <\/strong>Fifty-two percent of patients among different age groups were seroprotected. Seroprotection was significantly associated with the interval year after vaccination demonstrated at &lt; 50% 5 years and beyond post-vaccination.<br \/>\n<strong>Keywords:<\/strong> Hepatitis B seroprotection, Hepatitis B immunization, anti-HBs<br \/>\n<a href=\"https:\/\/doi.org\/10.56964\/pidspj20181901002\"><strong>https:\/\/doi.org\/10.56964\/pidspj20181901002<\/strong><\/a><br \/>\n<strong><a href=\"https:\/\/www.pidsphil.org\/home\/wp-content\/uploads\/2019\/02\/jo54_ja02.pdf\" target=\"_\" rel=\"noopener\">View Full Article in PDF format<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Journal 2018 Vol.19 No.1 A Prospective Cross-Sectional Study on the Prevalence and Factors Associated with Seroprotection after Primary Series of Hepatitis B Vaccination Adrienne Michelle B. Lu, M.D., Maria Estela R. Nolasco, M.D., Marilou G. Tan, M.D. Abstract Objectives: To determine the prevalence and factors associated with seroprotection among children 3 months to 18 years  [&#8230;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-17471","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/pages\/17471","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/comments?post=17471"}],"version-history":[{"count":7,"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/pages\/17471\/revisions"}],"predecessor-version":[{"id":20048,"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/pages\/17471\/revisions\/20048"}],"wp:attachment":[{"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/media?parent=17471"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}