{"id":17399,"date":"2022-08-28T06:41:06","date_gmt":"2022-08-28T06:41:06","guid":{"rendered":"http:\/\/www.pidsphil.org\/home\/?page_id=17399"},"modified":"2025-06-14T04:31:48","modified_gmt":"2025-06-14T04:31:48","slug":"journal-2020-vol-21-no-1-original-articles-2","status":"publish","type":"page","link":"https:\/\/www.pidsphil.org\/home\/journal-2020-vol-21-no-1-original-articles-2\/","title":{"rendered":"Journal 2020 Vol.21 No.1 Original Articles 2"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1206.4px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-text fusion-text-1\"><p><strong><span class=\"journalTitle\"><span style=\"color: #800000;\">Journal 2020 Vol.21 No.1<\/span><\/span><\/strong><br \/>\n<strong>Effectiveness and Adverse Effects of Intravenous Colistin In Neonates with Multi-Drug Resistant Gram-Negative Bacterial Infections<\/strong><br \/>\n<strong><em>M<strong>i<\/strong>chael N. Crisostomo, M.D., Cecilia Maramba-Lazarte, M.D.<\/em><\/strong><br \/>\n<strong>Abstract<\/strong><br \/>\n<strong>Background:<\/strong> The global burden of multi-drug resistant gram-negative bacterial (MDR-GNB) infections has been increasing.<br \/>\nNeonates are at a particularly high-risk and there is limited treatment option. The use of colistin has been re-introduced for this population. However, data on its use in neonates is scarce.<br \/>\n<strong>Objectives:<\/strong> To determine the effectiveness and adverse effects of intravenous colistin in neonates with multidrug-resistant gram-negative infections.<br \/>\n<strong>Design:<\/strong> This is a retrospective cohort study of the clinical profile and outcome of neonates with MDR-GNB infections given colistin for a minimum of 3 days conducted from April 2015 to April 2019.<br \/>\n<strong>Results:<\/strong> A total of 175 pediatric patients had MDR-GNB infections. 75 (43%) neonates met the inclusion criteri a and received intravenous colistin. Of the 75 patients with MDRGNB infections- that included sepsis, pneumonia, urinary tract infection and abscess, 37 (49.3%) were alive and 38 (50.7%) patients died. Nephrotoxicity was seen in 4% if patients and 2.6% patients had hypersensitivity reaction. MDROs isolated were Acinetobacter baumanii, Klebsiella pneumoniae and Pseudomonas aeruginosa.<br \/>\n<strong>Conclusions:<\/strong> Intravenous colistin is 50% effective and is relatively safe to use in neonates.<br \/>\n<strong>Keywords:<\/strong> colistin, MDR-GNB, neonates<br \/>\n<a href=\"https:\/\/doi.org\/10.56964\/pidspj20202101004\"><strong>https:\/\/doi.org\/10.56964\/pidspj20202101004<\/strong><\/a><br \/><strong><a class=\"fullscreen-mode\" href=\"https:\/\/www.pidsphil.org\/home\/themencode-pdf-viewer\/?file=https:\/\/www.pidsphil.org\/home\/wp-content\/uploads\/2020\/06\/Vol-21-No-1_CRISOSTOMO_Intravenous-Colistin-Final.pdf#zoom=auto\">Fullscreen Mode<\/a><br \/><iframe class=\"pvfw-pdf-viewer-frame\" width=\"100%\" height=\"800\" src=\"https:\/\/www.pidsphil.org\/home\/themencode-pdf-viewer\/?file=https:\/\/www.pidsphil.org\/home\/wp-content\/uploads\/2020\/06\/Vol-21-No-1_CRISOSTOMO_Intravenous-Colistin-Final.pdf#zoom=auto&amp;pagemode=none\"><\/iframe> <\/strong><\/p>\n<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-17399","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/pages\/17399","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/comments?post=17399"}],"version-history":[{"count":6,"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/pages\/17399\/revisions"}],"predecessor-version":[{"id":20010,"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/pages\/17399\/revisions\/20010"}],"wp:attachment":[{"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/media?parent=17399"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}