{"id":17334,"date":"2022-08-25T10:35:41","date_gmt":"2022-08-25T10:35:41","guid":{"rendered":"http:\/\/www.pidsphil.org\/home\/?page_id=17334"},"modified":"2025-06-14T04:20:12","modified_gmt":"2025-06-14T04:20:12","slug":"journal-2021-vol-22-no-1-case-reports","status":"publish","type":"page","link":"https:\/\/www.pidsphil.org\/home\/journal-2021-vol-22-no-1-case-reports\/","title":{"rendered":"Journal 2021 Vol.22 No.1 Case Reports"},"content":{"rendered":"<p><strong><span style=\"color: #800000;\">Journal 2021 Vol.22 No.1 <\/span><\/strong><\/p>\n<p><strong><span style=\"color: #800000;\">Case Report<\/span><\/strong><br \/>\n<strong>Fulminant Hepatic Failure in a SARS-CoV-2 Positive Pediatric Patient: A Case Report<\/strong><br \/>\n<em><strong>Jerrymae R. Blasurca, M.D.<\/strong><\/em><br \/>\n<strong>Abstract<\/strong><br \/>\nRespiratory symptoms are the most common manifestation of COVID-19 across all age groups and it is most often associated with radiographical findings consistent with pneumonia.2 A recent systematic review estimated that 16% of children with SARS-CoV-2 infection are asymptomatic,3 or others may present with seizures, gastrointestinal bleeding or jaundice. This reports a 2-year old boy with no known co-morbidity who had a 2-week history of abdominal pain and jaundice then had a rapidly progressive course of neurological deterioration and eventual demise. He had markedly elevated liver enzymes and deranged bleeding parameters with elevated ammonia and ferritin levels. Hepatitis B and hepatitis A titers were non-reactive. He was managed as a case of hepatic encephalopathy secondary to cholestatic jaundice. His chest x-ray was normal but his SARS-CoV-2 RT PCR result was positive with a low cycle threshold. Locally, this is the first reported case of SARS-CoV-2 RT-PCR positive pediatric patient presenting as fulminant hepatic failure with no associated respiratory manifestations. Clinicians should be mindful that such presentation, however uncommon, is possible and a high index of suspicion should be maintained.<br \/>\n<strong>Keywords:<\/strong> COVID-19, SARS-CoV-2, hepatic failure, fulminant hepatitis, case report<br \/>\n<strong><a href=\"https:\/\/doi.org\/10.56964\/pidspj2021220103\">https:\/\/doi.org\/10.56964\/pidspj2021220103<\/a><\/strong><br \/>\n<strong><a href=\"https:\/\/www.pidsphil.org\/home\/wp-content\/uploads\/2021\/05\/03-Vol-22-No-1_Blasurca_Fulminant-Hepatic-Failure-in-a-SARS-CoV-2-Positive-Pediatric-Patient_A-Case-Report_FORMATTED_v3.pdf\" target=\"_\" rel=\"noopener\">View Full Article in PDF format<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Journal 2021 Vol.22 No.1 Case Report Fulminant Hepatic Failure in a SARS-CoV-2 Positive Pediatric Patient: A Case Report Jerrymae R. Blasurca, M.D. Abstract Respiratory symptoms are the most common manifestation of COVID-19 across all age groups and it is most often associated with radiographical findings consistent with pneumonia.2 A recent systematic review estimated that 16%  [&#8230;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-17334","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/pages\/17334","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/comments?post=17334"}],"version-history":[{"count":8,"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/pages\/17334\/revisions"}],"predecessor-version":[{"id":19984,"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/pages\/17334\/revisions\/19984"}],"wp:attachment":[{"href":"https:\/\/www.pidsphil.org\/home\/wp-json\/wp\/v2\/media?parent=17334"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}